Is C# part of the problem?

[MadBlaster]

These points stand out.

"Now here's the rub. Marshalling is computationally expensive, and the more data you move back and forth, the more expensive it becomes. Marshalling data structures one way can add as much as 3,000 instructions to your processing time for complex data. "


"By investing a little time early in the development phase, you can ensure that you made the right performance choice and not have to go back and make substantial changes after you have a working application. "


Can we call CLoD a case study at this point?

Jmho, the author comes across bias to managed mode programming. It's a good article though. Hopefully CLoD coders have access to the tool(s) the author speaks about to optimize the interop.