Game Doesn't Run GTX 480

[nakedsquirrel]

I tried uninstalling and re-installing my drivers, game, and deleting the shaders cache and the game still crashes after I start the Launcher.exe. Sometimes I get a black screen and sometimes I get the windows pop-up 'this program has stopped working'

This is the only game I've had any issues with.

I'm running Windows Vista, x64 bit
i7 processor
6GB Ram
and I recently put in a GTX480 and my old sound card:
GTX480
Sound Blaster Xfi

I was running 2 GTS 250s in SLI