I'd say the first priority has to be at least Distortion I, Chaos I, and Order I. Then work your way along to Higher Magic I, Distortion III, and Transmutation I. That'll use up your first 65 mana runes. After that, it's really a matter of personal preference - if you like dealing direct damage, Chaos and Destruction are good bets. If you prefer using summons and playing a patient game trying to avoid damage, Summoner and Order are good choices. If you're more of a buffer and de-buffer, Order and things to boost your intelligence. If you find yourself chronically short of mana, consider Transmutation and Concentration. I'd avoid Alchemy, but really all the other skills in the magic tree can be quite useful.
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