how to trim properly

[Bolelas]

Its not about game use, i know the keys/axis etc. The elevetor trim i know how to use properly(or i think i know). My question is, in planes that have rudder and aileron trim, how do i know the amount of trim to apply from eatch one? Look at the slip ball? Torque that afects our aircraft is mainly from 4 forces:
Reactive force( blades hiting the air, more intense at low speed, high engine rotation)-shold correct with rudder trim or aileron trim? ( i think aileron)

Spiraling sleepstream, this air hits the plane in one side of the tail, and i think should be corrected with rudder trim.

Giroscopic prececion, aplies strenght 90 degrees from aplied force. i think aileron trim here, but since it is only noted on changes of engine rotation, i think no need to trim.

P factor, at high angles of atack the diferent forces aplied on uper and down blades are diferent and produce more Yaw. i gess no need to trim here, we dont fly alway on high angle of atack.

And of corse there is te weight balance, but dont think it applies here in the sim, (ex having a fat copilot...)

And how about planes with no aileron trim, how do i know the amount of rudder trim so that the plane flies as fast as possible?