Since both Bf 110 and P-51 were mentioned...
Bomber interception in Bf 110 was one of my favourite tasks in 2016/2017 winter season online. For example on Italy map there:
http://www.letkaorel.eu/fusion7/foru...?thread_id=228
A map chopped down, indeed.
But as true hard core interceptor you need a lot of time to wait for your pray. 100% fuel and drop tanks and the heaviest weaponry available... harder the merrier

After 50 min of cruising you finally spot those 12 x B-17s...patience pays.

And withdrawing from the last attack with internal tank punctured you were glad that you did not save on the fuel before the take off.
But who was my nemesis? That smart ass P-51 who just scrambled every 20 min with minimum fuel load as soon as bombers began to shout "we are under attack" and who occasionally caught me with my pants down near the bombers formation. I did wish him to carry 100% fuel, damned !
Sorry, I have digressed.