I have been reading the threads and i too have immense slowdown despite running a new Alienware Area 51 ALX. I have an Nvidia 480x, a I7 x980 processor and loads of ram but still have slowdown (partial freezing). This should not happen on my rig as i fly through Ass effect 2, Shogun 2 and Dragon age on max without a sweat.
As soon as this game launches and you click on any button, it takes close to 5 minutes to launch the next screen, so there is definately a major bug.
Until these issues are properly addressed i would advise anyone to hold off buying or at the very least test the demo ad infinitum first to ensure you dont have the same experience