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and make sure it has positive pressure inside
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I'm not sure that's possible... the air has to get in somehow to be blown out again.
Positive pressure on the inside of a biohazard suit for example is achieved by pressurising it with some outside (or canister) air source, meaning any compromise in the suit's skin would result in air coming out instead of air (and whatever else) going in.
I'm not sure this is applicable to computer cases, unless you have some dust-free air source being piped in through a tube out of the window
Sorry, just an opportunity to write about a cool thing I saw in a drama movie/book about a disease outbreak!