Don't worry about it too much, it's not really that complex. Adjust mixture down when you start losing power, trailing smoke. Adjust it back up when you can, it cools the engine and appears to not increase fuel consumption. Reduce rpm along with power, you'll might be faster while keeping the engine cooler. Try to keep radiators closed, they cost speed and range. It might be necessary to open them when using high power settings, otherwise the engine blows.
Personally I tend to cruise at around 60% pitch/power radiators closed, climb at around 90% radiators open. In combat I do what's necessary, usually 95% pitch and 105% power with rads open.
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