Sounds like corrupt files to me.
Did you ever closed the game improperly by terminating the task, or did your computer crash while the game was open?
Either way you could've ended up with corrupt files.
If it's a problem with the saves, try loading a earlier one and going directly to Upper Hadar, to see if it happens again.
If it's with other gamefiles, reinstall the game and retry the save.
Also if you did in fact had a crash, schedule a scandisk for your next boot.
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