Aye, same here. I've noticed that once I couldn't get a rune in some cave, and walked forth and back. Might've been the same rune you're talking about, as I'd recall there was another rune beside it I could get.
I couldn't get it by clicking on it, but I could get it through this way:
Moving my character by holding the mouse button and steering him close enough, he managed to get into a position where the autopathfinder couldn't get him into. Then I was close enough to grab the rune.
Kaer
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