I've just tried it and it works for me. I forced ON v-sync (I thought) with CCC, closed CCC and started game, no V-sync. I closed game, opened CCC and v-sync was OFF, I forced it ON, applied it (for sure) and started game with CCC open. v-sync was ON. I was sure I applied setting first run through and if I did I don't know if leaving CCC open made any difference. Now back to normal with v-sync OFF.

I have an HD7970 with 13.2 Beta 5 driver on Win7 64 and game in opengl.