A few years ago i've started playing IL2 using this type of joystick. One thing I can tell you: I've never used any profile! I've just went in game - controls and chose what I needed to bind.
My piece of advice: try to use only the X52 throttle in combination with another joystick, preferably Microsoft Sidewinder Forcefeeback 2, knowing the fact that X52 joystick is not so reliable.
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