The Tu-4 / B-29 has very good high altitude performance and can maintain about 600 km/h were the Ta 152C can maintain 700 km/h. While a speed advantage of 100 km/h may sound like a lot at the first glance, it in fact isn't that much. While you can eventually catch them, it will certainly take you a while.
The Ta 152C also has a very high wing loading, that is a very small wing for its weight and a low power loading, that is little power for its weight. You can't expect it to have good low speed performance, so you have to keep it fast - no stall turn or low speed climbs, a lot of planes can do that a lot better. You'll have to stick with hit and run tactics, where the excellent speed and firepower come in very handy.
As opposed to what jermin claims, the Ta 152C has actually received a boost in performance with the 4.11 patch, it about achieves the same performance it previously did, but does so with an 175kg extra fuel. Which brings up the next point - the plane does carry a lot of fuel - around 850 kg, more than a P-51. This means that in single missions you can probably fly it with as little as 20% fuel and still have plenty. You will certainly notice a considerable increase in climb and turn performance, but it will still be rather poor.
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