There really is no one "right" answer. The best idea is to put your runes into skills that compliment your playstyle. If you like to cast spells, then put points into spell casting. If you prefer to do the brute force approach, put them into melee. You're not likely to go wrong with most choices that you make. Just keep in mind that if you go with spells, that you'll want to improve the spell schools for the spells you cast the most.
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