Hi
I use the Medusa Amplified head set they seem to be more powerful than the usb ones.
Settings are plentiful if you have a Audigy1/2/Xfi/Soundblaster cards.
In IL2 folder there's an icon called setup hit that and try the settings under the sound tab you will have to play around with that to see what sounds best.
If you have one of the soundcards as mentioned above there are CMSS 3D settings in the creative audio console to really get the best sound out of these headphones.
Have fun