Before I got my current build I ran it on a 3.5GHz E7400, so I think your CPU will work well enough. I did have a GTX 460 (also OCed) though.
I'm not sure how well your GPUs will work. I don't think they'd really cut it with the current version (I could be wrong), but depending on what exactly was optimized in the next patch you may be okay with what you have.
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i5-2500K @ 4.5GHz | 8GB DDR3-1600 | GTX 560Ti-448 (1.25GB) @ 925MHz | TrackIR 5 | X52(Modded), Saitek Pedals | Win7-64
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