It's a loosing battle with the LaGG-3 for the most part. The biggest question right off the bat is ... which LaGG-3? Series 4, 29, 35, or 66?
In general the LaGG-3 is always at a disadvantage as it weighs more than a 109, has a less powerful engine, and will easily go down under sustained fire. The fuselage is pretty strong but the internal components are fairly weak.
The Series 35 is the first one that really has a solid chance with a beefed up engine and some aerodynamic improvements. The Series 66 is nearly on par with the 109s but it's still inferior. I would use the tried and tested methods of aerial combat: have a better position, spot the enemy before they do, engage aggressively and fire effective short bursts.
If you do get in close the LaGG does turn fairly well over short distances so you may be able to pull lead on a maneuvering 109. Don't follow him for too long as they still have the overall advantage in turn.
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