I understand your desire for some change and all that. In the end you'll play whatever you want to play and whatever provides you with the fun you wanted to have :> I'm just poop shooting terrible ideas xD In the end, you decide.
If you want challenge: play no-loss
With a Mage. On impossible diff. Have fun :> If you make it through Demonis and the Labyrinth without losses, you can still start 5-melees-with-crappy-stats games ^^