Could be great, but the last AvP left a bad taste in my mouth. The best thing about the original AvP, which was a great game, was the Marine campaign. Particularly the movie sounds they incorporated, and the atmosphere created by only being able to use the motion tracker with your nightvision disabled.
I don't have much faith in Gearbox anymore either. And considering Duke Nukem was a failure and the layoffs they had there recently, I won't be rushing out to buy this until many, many reviews are in.