Nice to see that you tried to use CEM. The basics aren't that difficult and your plane will (most of the times) fly better than without CEM, even if your settings are a bit off. It takes a bit of practice and reading to get the best out of CEM. But even for a novice it can be really worthwhile and fun. Once you get the hang of it, you will never go back.
Don't worry too much about your trim. Try trimming your plane once you're up to speed. And remember it will never be completely perfect. Besides, every change in speed, altitude, RPM, pitch and radiator will have influence. Sometimes it's good to make some corrections to your trim. But don't overdo it. With a plane like the spitfire, you have to accept you need to correct with your joystick almost constantly.
You also mentioned the BF110. This is one of my favorite planes in CloD and it's pretty easy to get an almost perfect trim. Trimming is not a real substitute for autopilot. However, I'm able to get it straight enough to pay a quick visit to the toilet or get a drink and find it still more or less on course when I come back.
Bombers can sometimes be really hard to get. Especially when they are flying with full throttle and higher than you are. Thereby, the Spitfire 1a isn't the fastest plane in a straight line. But luckily this isn't an arcade game where the enemy can fly unrealistic speeds. If you can't get an enemy, it's because the enemy has a faster plane, your settings aren't optimal or maybe a bug in the game.
Good luck and lots of fun! I think you are getting there...