Most performance issues with ATI/AMD GPUs and Cliffs of Dover can be attributed to the fact the game does not run in a full-screen mode like every other DirectX game out there. This is breaking the drivers on many levels including stopping the Catalyst Control Center from having any effect in-game in terms of applied settings as well as causing the game to be ignored as a 3D program which has the follow-on effect of 3d clock speeds not being applied properly.
Would like an update in regards to the full-screen situation, it was mentioned last patch it would be added in but its still not here.
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