From everything I've seen, the only thing I can definitely tell you to look for is an HD 6950/70 2GB for a video card. The GTX 570 and GTX 580 may be faster in other games, but for Cliffs of Dover the HD 6900s have an edge thanks to their 2GB of VRAM.
As far as the CPU goes, get the best you can afford. For me, that was AMD, and I'm very pleased. My 955BE does 3.6GHz without touching the voltages and the CPU and Motherboard cost me under $300 USD. In terms of price/performance, you can't beat an AMD system right now. However, if you can afford an i5 or i7 2X00, by all means go for it.
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