Medusa 5.1 all the way, I've had the v2 for about 4 years now with no problems with the sound quality. The vinyl around the ear cups is only now breaking up and pealing so I think I'm due for a new pair, but I will be buying Medusa again (non USB)
If you have an X-Fi with a CMSS-3D ship you can experience binaural sound.
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