S!
ATI is planning the Southern Island refresh for their current lineup, which should boost the tesselation etc. Next year they launch the new Northern Island series with newer architecture. I bet nVidia will refresh their lineup as well and launch the 512-bit versions of their 4xx-series. IMO any current DX11 card in either SLI or XFire should be able to run SoW at acceptable FPS with decent eyecandy.
If SoW does utilize 4 cores as stated here, you will be good with any multicore CPU, be it AMD or Intel. They are overclockable so performance should really not be an issue. I think you need a lot of RAM with SoW.
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