S!
First off check that your conf.ini is not as "Read only". Right click it and see Properties. Uncheck Read Only if there is a tick. Also when changing conf.ini make sure you do the changes to the correct section, for example Render OpenGL if changing the OGL settings.
The issue with wide screens is a known issue and can not be fixed unless you use a modification. Also what helps, not with loading screens, for game itself showing is to set Save Aspect to 0 in conf.ini, just below the resolution settings.
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