I have a 30" monitor, Intel dualcore e6600 @ 2.88GHz, 2G of ram, nvidiot 8800GT, WinXp. While testing with the 2560*1600 resolution and highest details levels, the fps rate was manageable / playable, not great .. avg. of maybe 40fps. Bad fps over cities and such as expected.
Offtopic:
But the reason I am NOT using the full native resolution is that the physical size of one pixel (read: "enemy plane"

) is just too small for my eyes. Hence I use the 75% of the native which happens to be the 1920*1200. Enemies are now a bigger blob of pixels and this enhances the detection rate by 100000% (numbers calculated with the fully scientific Stetson-Harrison -method

). Waste of resolution, I know, but enemy detection is more important to me than few wasted pixels.