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Airframe icing isn't really a concern at very high altitudes as most of the moisture in the air is already frozen.. Though equipment icing (i.e. guns) can be a problem, hence the practice of taping up gun ports prior to take-off to prevent water ingress and subsequent freezing at altitude.
Airframe icing is more likely to accumulate at lower altitudes when taking a cold-soaked airframe through cloud or climbing through a warm front.
W.
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