CRT=2 and Wine does not work, at least out of the box. The reason is that CRT=2 makes checks outside game too. There were situations when CRT=2 was causing problems just because of different Windows versions (W2K server + XP client if I recall correctly) and even locales (i.e. Japanese). I had no time to try this, but I think it could work if you took system DLLs from Windows and put them inside Wine tree, so that they would be used instead of Wine "substitutions".
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