I had a similar problem with installing over a clean copy of 4.08m - a SecuRom error! It's been a long time since I saw one of those 
Even when I put in the disc it wouldn't work: told me I had the wrong disc and shut me down. To get around this, I asked a mate of mine who had a non-SR version with 4.09 installed to send me his il2fb.exe file, and that worked just fine.
Also, I fixed up a mate of mine by getting him to substitute his new mg_snd and mg_snd_sse dll files for the originals in 4.08. He was having the same symptoms as you Zent, and has a similar rig also.
B
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Another home-built rig:
AMD FX 8350, liquid-cooled. Asus Sabretooth 990FX Rev 2.0 , 16 GB Mushkin Redline (DDR3-PC12800), Enermax 1000W PSU, MSI R9-280X 3GB GDDR5
2 X 128GB OCZ Vertex SSD, 1 x64GB Corsair SSD, 1x 500GB WD HDD.
CH Franken-Tripehound stick and throttle merged, CH Pro pedals. TrackIR 5 and Pro-clip. Windows 7 64bit Home Premium.
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